Bardwell Lab
USEFUL
LINKS
The Bardwell Lab is in the Department
of Developmental and Cell Biology of the School
of Biological Sciences at the University of
California, Irvine.
Graduate students in the Bardwell lab participate in a multi-departmental Graduate Training Program
with academic tracks in
The Bardwell Lab belongs to the
Research Interests
We use molecular biology, biochemistry, genetics, cell biology and
math/computation to study fundamental questions of cell signaling and
regulation.
- Regulation of mitogen-activated protein kinase
(MAPK) cascades in yeast and mammalian cells.
- Mechanisms of specificity in signal
transduction, especially protein kinase signaling.
Signal
transduction networks are a crucial part of the circuitry by which a cell
regulates and coordinates its growth and developmental program, and its
response to the external environment. Faulty or malfunctioning signaling
pathways lie at the heart of the molecular pathology of many diseases,
including cancer. The signaling components we study have been highly conserved
through evolution, and are thus of great importance to basic biology, as well
as medicine.
See our recent publications to get a better idea of what we do.
Selected
Recent Publications
- L
Bardwell, X Zou, Q Nie and N
Komarova (2007)
Mathematical models of specificity
in cell signaling.
Biochemical Journal 92:3425-41.
Abstract
- L
Bardwell (2006)
Mechanisms of MAPK signalling
specificity.
Biochemical Society Transactions 34:837-41. Abstract
- L
Bardwell and K Shah (2006) L Bardwell, X Zou, Q Nie and N Komarova (2007)
Analysis of mitogen-activated
protein kinase activation and interactions with regulators and substrates.
Methods 40:213-23. Abstract
- DT
Ho, AJ Bardwell, S Grewal, C Iverson and L Bardwell (2006)
Interacting JNK-docking sites in
MKK7 promote binding and activation of JNK mitogen-activated protein
kinases.
Journal of Biological Chemistry 281:13169-79. Abstract
- S
Grewal, DM Molina and L Bardwell (2006)
Mitogen-activated protein kinase
(MAPK)-docking sites in MAPK kinases function as tethers that are crucial
for MAPK regulation in vivo.
Cellular Signalling 18:123-134.
Abstract
- DM
Molina, S Grewal and L Bardwell (2005)
Characterization of an ERK-binding
domain in MITF and differential inhibition of ERK2-mediated substrate
phosphorylation.
Journal of Biological Chemistry 280:42051-60. Abstract
- NL
Komarova, X Zou, Q Nie and L Bardwell (2005)
A theoretical framework for
specificity in cell signaling.
Molecular Systems Biology, doi:10.1038/msb4100031, E1-E5. Online/pdf
- LJ
Flatauer, S Zadeh and L Bardwell (2005)
MAP Kinases With Distinct
Requirements for Ste5 Scaffolding Influence Signaling Specificity in
Yeast.
Molecular and Cellular Biology 25: 1793-1803. Abstract
-- Get pdf
- L
Bardwell (2005)
A walk-through of the yeast mating
pheromone response pathway.
Peptides 26 339-350.
Abstract
-- Download
pdf
- PJ
Cullen, W Sabbagh, M Irick, E Graham, E van Olden, C Neal, J Delrow, L
Bardwell and GF Sprague, Jr. (2004)
Msb2 is a Signaling Mucin at the
Head of the Yeast Filamentous Growth MAPK Pathway.
Genes & Development 18:1695-1708. Abstract
- AB
Kusari, DM Molina, W Sabbagh Jr., C Lau and L Bardwell (2004)
A conserved protein interaction
network involving the yeast MAP kinases Fus3 and Kss1.
Journal of Cell Biology 164:267-277. Abstract
-- Get pdf
- AJ
Bardwell, M Abdollahi and L Bardwell (2004)
Anthrax lethal factor-cleavage
products of mitogen-activated protein kinase (MAPK) kinases exhibit
reduced binding to their cognate MAPKs.
Biochemical Journal 378:569-577. Abstract
-- Get pdf
- DT
Ho, AJ Bardwell, M Abdollahi and L Bardwell (2003)
A docking site in MKK4 mediates
high-affinity binding to JNK MAP kinases and competes with similar docking
sites in JNK substrates
Journal of Biological Chemistry 278:32662-72. Abstract
- AJ
Bardwell, M Abdollahi and L Bardwell (2003)
Docking sites on mitogen-activated
protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1
transcription factor compete for MAPK binding and are crucial for enzymic
activity
Biochemical Journal 370:1077-1085. Abstract
- W
Sabbagh Jr, LJ Flatauer, AJ Bardwell and L Bardwell (2001)
Specificity of MAPK signaling in
yeast differentiation involves transient vs. sustained MAPK activation
Molecular Cell 8:683-691.
Abstract
- AJ
Bardwell, LJ Flatauer, K Matsukuma, J Thorner and L Bardwell (2001)
A conserved docking site in MEKs
mediates high-affinity binding to MAP kinases and cooperates with a
scaffold protein to enhance signal transmission
Journal of Biological Chemistry 276:10374-10386. Abstract
Last
modified 1 May 2008. Back to top